Hadge: a Comprehensive Pipeline For Donor Deconvolution in Single-Cell Studies Single-cell multiplexing techniques (cell hashing and genetic multiplexing) combine multiple samples, optimizing sample processing and reducing costs. Cell hashing conjugates antibody-tags or chemical-oligonucleotides to cell membranes, while genetic multiplexing allows to mix genetically diverse samples and relies on aggregation of RNA reads at known genomic coordinates. We develop hadge (hashing deconvolution combined with genotype information), […]
https://lifeboat.com/blog/2024..../04/hadge-a-comprehe