Efficacy and Safety of Lumasiran for Advanced Primary Hyperoxaluria Type 1: 24-Month Follow-Up of the Phase 3 Illuminate-C Trial Primary hyperoxaluria type 1 (PH1) is a rare autosomal recessive disorder caused by hepatic alanine-glyoxylate aminotransferase deficiency, leading to oxalate overproduction which results in progressive kidney damage and increased urinary oxalate (UOx) and plasma oxalate (POx) levels.1,2 Oxalate accumulation can result in kidney stones, nephrocalcinosis, and kidney failure.2 In chronic kidney disease stages 3b−5, elevated POx increases the risk of calcium oxalate deposition (systemic oxalosis) in the heart, bones, eyes, and other organs.
https://www.ajkd.org/article/S....0272-6386(25)00729-2

To Shower or Not to Shower? Personal Hygiene, Safety, and Patient Choice in Hemodialysis Catheter Care In the United States, more than 90,000 patients commence dialysis annually via a central venous catheter (CVC) and more than 100,000 prevalent patients use a CVC as a primary vascular access for hemodialysis.1 The use of CVCs for hemodialysis is associated with an increased risk of infection and mortality compared to a fistula or graft. The most recent US National Healthcare Safety Network Dialysis Event Surveillance Report, which includes data from 7,129 dialysis clinics, noted that the rate of bloodstream infections (BSI) in patients with CVCs was 7-fold higher than those with fistulas and 4-fold higher than those with a graft.
https://www.ajkd.org/article/S....0272-6386(25)00692-4

A difficult path to point-of-care measurement of glomerular filtration rate https://www.nature.com/articles/s41581-025-00947-0

Neighborhood Built Environment and Home Dialysis Utilization: Varying Pattens by Urbanicity-Dependent Patterns and Implications for Policy Despite national efforts, uptake of home dialysis (peritoneal dialysis or home hemodialysis) remains low. Characteristics of the built environment may differentially impact home dialysis utilization.
https://www.ajkd.org/article/S....0272-6386(25)00719-X

The role of implementation science in advancing equity in kidney health https://www.nature.com/articles/s41581-025-00949-y