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Differing patterns of cortical grey matter pathology identified by multifractal analysis in UMN-predominant ALS patients with and without corticospinal tract hyperintensity The pathological hallmarks of amyotrophic lateral sclerosis (ALS) are degeneration of the primary motor cortex grey matter (GM) and corticospinal tract (CST) resulting in upper motor neuron (UMN) dysfunction. Conventional brain magnetic resonance imaging (MRI) shows abnormal CST hyperintensity in some UMN-predominant ALS patients (ALS-CST+) but not in others (ALS-CST–). In addition to the CST differences, we aimed to determine whether GM degeneration differs between ALS-CST+ and ALS-CST– patients by cortical thickness (CT), voxel-based morphometry (VBM) and fractal dimension analyses.
https://www.jns-journal.com/ar....ticle/S0022-510X(24)


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Retraction notice to Cerebrospinal fluid atypical lymphocytes in Japanese encephalitis” [JNS 160 (1998) 92–95] This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about..../policies/article-wi
https://www.jns-journal.com/ar....ticle/S0022-510X(24)


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Plasma GFAP as a prognostic biomarker of motor subtype in early Parkinson’s disease https://www.nature.com/articles/s41531-024-00664-8


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Assessment of a one-week ketogenic diet on brain glycolytic metabolism and on the status epilepticus stage of a lithium–pilocarpine rat model https://www.nature.com/articles/s41598-024-53824-4


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The tauopathy‐associated PERK variant, PERK‐B, induces maladaptive translation and reveals novel pathogenic mechanisms of PSP Congratulations to Dr. Karen McFarland on the publication of “The tauopathy‐associated PERK variant, PERK‐B, induces maladaptive translation and reveals novel pathogenic mechanisms of PSP” which appears in the December issue of Alzheimer’s and Dementia. Abstract Background A major challenge in the field is identification of molecular mechanisms driving pathological tau accumulation in tauopathies such as…
https://neurology.ufl.edu/2024..../02/29/the-tauopathy


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