Inhibiting P16 in Microglia Reduces Amyloid Plaques in Mice Researchers here show that targeting microglia in a mouse model of Alzheimer's disease to suppress p16 expression can reduce amyloid-β plaques. This appears to be a way to interfere in a maladaptive reaction to amyloid-β on the part of microglia, innate immune cells responsible for clearing molecular debris from brain tissue. P16 is a marker of cellular senescence, though may also be characteristic of non-senescent but still problematic, pro-inflammatory microglia. There is a good amount of evidence to suggest that both senescent and overly active microglia are important to the progression of neurodegenerative conditions such as Alzheimer's disease. Senescent cells can be cleared by senolytic therapies, and evidence in animal studies suggests that this should help Alzheimer's patients. Dealing with non-senescent, activated and problematic microglia […]
https://www.fightaging.org/arc....hives/2024/03/inhibi