Fight Aging! Newsletter, May 12th 2025 Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Suppression of the Senescence-Associated Secretory Phenotype as a Basis for Therapy Circulating Proteins Secreted by Senescent Cells Correlate with Risk of Mild Cognitive Impairment A Mechanism by Which TDP-43 Aggregation Causes Pathology in the Aging Brain Contrasting the Strategies […]
https://www.fightaging.org/arc....hives/2025/05/fight-

A High Level Tour of Environmental Contributions to Aging Primary aging derives from mechanisms inherent to our biology, such as the damaging mechanisms listed in the Strategies for Engineered Negligible Senescence (SENS) view of aging. Secondary aging derives from lifestyle choices (such as diet and exercise) and environmental exposures (such as particulate air pollution or persistent viral infections), harmful factors that can interact with the mechanisms of primary aging to accelerate the path to loss of function, age-related disease, and mortality. Epidemiological studies suggest that many people are losing at least a few years of life to poor choices, poor luck, or poor living circumstances. Today's open access paper offers a high level tour of some of the major categories of environmental pollution. While extensive data indicates air pollution is harmful and increases the […]
https://www.fightaging.org/arc....hives/2025/05/a-high

Replacing an Extracellular Matrix Component to Treat Degenerative Disc Disease The extracellular matrix is a complex structure of molecules generated and maintained by cells to support themselves and determine the physical properties of a tissue, such as load-bearing capacity or elasticity. The extracellular matrix changes with age in ways that are not fully explored, but which harm cells and tissue function. Comparatively little effort is focused on finding ways to repair the aged extracellular matrix, in part because it seems a hard problem. There are few points of intervention that can be as simple as the one noted here, where delivering a novel substitute molecule allows it to be incorporated into the matrix to improve matters. In most cases, providing the raw materials is not enough; there are issues of cell activities, problematic alterations to […]
https://www.fightaging.org/arc....hives/2025/05/replac

Towards PET Scan Detection of α-Synuclein for Early Diagnosis of Parkinson's Disease Researchers here note recent progress towards assessment of the burden of misfolded α-synuclein in a living brain via contrast imaging. This would provide a way to reliably diagnose Parkinson's disease in advance of symptoms. Unlike imaging for the protein aggregates associated with Alzheimer's disease, this is not an established capability. It seems likely that imaging approaches will fade in importance in the years ahead, however, as blood assays with a much lower cost are now demonstrated to be able to detect neurodegenerative diseases in their earliest stages. The abnormal accumulation of α-synuclein protein is a defining pathological feature of several neurodegenerative conditions collectively known as synucleinopathies, including Parkinson's disease (PD), multiple system atrophy (MSA), and dementia with Lewy bodies (DL. Until recently, confirming the presence […]
https://www.fightaging.org/arc....hives/2025/05/toward

Clusterin Expression is a Signature of Age-Related Hematopoietic Stem Cell Dysfunction Hematopoietic stem cells in the bone marrow generate red blood cells and immune cells. Immune cells can be roughly divided into myeloid lineages of the innate immune system and lymphoid lineages of the adaptive immune system. With advancing age, the generation of myeloid cells becomes favored over lymphoid cells, and this is one source of dysfunction in the aged immune system. Here, researchers find a signature of age-related dysfunction in hematopoietic cells that favor myeloid cell production. This could be a first step towards targeting these malfunctioning hematopoietic cells in order to restore a more balanced generation of immune cells and thus improve immune function in older individuals. Hematopoietic stem cells (HSCs) exhibit significant age-related phenotypic and functional alterations. Although single-cell technologies have elucidated age-related […]
https://www.fightaging.org/arc....hives/2025/05/cluste