Endothelial Cellular Senescence Contributes to Loss of Capillary Density The consensus of the research community on senescent cells in old tissues is that (a) their presence causes harm, and (b) treatments based on the selective removal of such cells will be beneficial, reversing many aspects of aging and age-related disease. These cells secrete a pro-inflammatory mix of signal molecules that is disruptive to tissue structure and function when maintained over time. Cells become senescent constantly throughout life, only to be destroyed by programmed cell death or by the immune system. With advancing age, newly created senescent cells are cleared ever more slowly, however, and thus the burden of lingering senescent cells grows throughout the body. As the authors of today's open access paper note, the presence of senescent endothelial cells in blood vessel walls […]
https://www.fightaging.org/arc....hives/2024/04/endoth