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More on the Anti-Inflammatory Activities of BPIFB4 in Long Lived Individuals A research team has recently investigated a role for BPIFB4 in human longevity. They have identified a variant of this gene that appears more often in a population of long-lived individuals than in other people. They have also investigated how this gene might influence aging; the present view is that it acts to make a larger fraction of monocytes and macrophages adopt the M2 anti-inflammatory phenotype than would otherwise be the case. Chronic inflammation is highly influential in the progression of aging and age-related disease, and thus we should probably expect long-lived individuals to exhibit better control of inflammation to at least some degree. In industrialized countries, lifespan averages 78 for males and 83 for females, but some exceptional individuals delay aging and live much […]

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