A mutation in Themis contributes to anaphylaxis severity following oral peanut challenge in CC027 mice The development of peanut allergy is due to a combination of genetic and environmental factors, although specific genes have proven difficult to identify. Previously, we reported that peanut-sensitized CC027/GeniUnc (CC027) mice develop anaphylaxis upon oral challenge to peanut, unlike C3H/HeJ (C3H) mice.
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Antibiotics within first year are linked to infant gut microbiome disruption and elevated atopic dermatitis risk https://www.jacionline.org/art....icle/S0091-6749(24)0

Biologic and Small Molecule Therapy for Treating Moderate to Severe Atopic Dermatitis: Mechanistic Considerations Atopic dermatitis (AD) is a complex and heterogeneous skin disease where achieving complete clinical clearance for most patients has proven challenging through single cytokine inhibition. Current studies integrate biomarkers and evaluate their role in AD, aiming to advance our understanding of the diverse molecular profiles implicated. While traditionally characterized as a Th2-driven disease, extensive research has recently revealed the involvement of Th1, Th17, and Th22 immune pathways, as well as the interplay of pivotal immune molecules, such as OX40, OX40 ligand (OX40L), thymic stromal lymphopoietin (TSLP), and IL-33.
https://www.jacionline.org/art....icle/S0091-6749(24)0

Alzheimer’s Incidence and Prevalence with and without Asthma: A Medicare cohort study International data suggest that asthma, like other inflammatory diseases, might increase Alzheimer’s disease (AD) risk.
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Can sputum eosinophils predict a poor response to mepolizumab? https://www.jacionline.org/art....icle/S0091-6749(24)0