Towards Engineered Mitochondria for Therapy Cells can take up mitochondria from the surrounding environment, and researchers have demonstrated in mice that intravenous delivery of mitochondria allows some degree of replacement of the native populations in cells. This improves function when native mitochondria are dysfunctional, as occurs with age. At present, delivery of mitochondria as a therapy to restore mitochondrial function in older people is a work in progress. A few companies are working on the challenge, which largely involves developing the techniques needed to reliably manufacture mitochondria at scale. In this paper, researchers look beyond that effort to the next step in the road, which is to engineer the delivered mitochondria to be more efficient and more resilient, or to act as factories for therapeutic molecules, or to have some […]
https://www.fightaging.org/arc....hives/2025/10/toward

Reviewing the Development of Senolytic Therapies for Neurodegenerative Conditions Senescent cells accumulate with age in tissues throughout the body, generating sustained pro-inflammatory signaling that is increasingly disruptive to tissue structure and function. This is an important contribution to degenerative aging, as illustrated by the many animal studies in which senolytic therapies that selectively destroy senescent cells produce significant reversal of aspects of aging and age-related disease. Here, researchers review the evidence for senolytic therapies to effectively treat neurodegenerative conditions by removing the harms done by senescent cells in the brain. The cellular phenomenon of aging is irreversible and is characterized by the arrest of cell division and induction of growth. It is believed that this mechanism contributes to age-related illnesses, such as neurodegenerative diseases, as well as the ageing process itself. The ability of […]
https://www.fightaging.org/arc....hives/2025/10/review

Recent Progress Towards Measures of the Burden of Cellular Senescence Cells become senescent constantly, ceasing to replicate and generating inflammatory signaling. This occurs when cells reach the Hayflick limit on replication, and in response to damage, injury, and toxicity. Senescence helps to draw the attention of the immune system to where it is needed, and in youth senescent cells are efficiently destroyed by immune cells once that task is accomplished. With age, however, the immune system becomes progressively less efficient while the environment becomes more damaged. As a consequence a burden of lingering senescent cells grows over time, and their contribution to the chronic inflammation of aging disrupts tissue structure and function. Usefully measuring the burden of senescence in older people in a low-cost, non-invasive way remains a work in progress. In principle different tissues […]
https://www.fightaging.org/arc....hives/2025/10/recent

Physical Activity Correlates with Improved Benefits from Calorie Restriction in Humans The CALERIE study of human calorie restriction was conducted some years ago. Participants aimed at 25% calorie restriction and achieved a ~12% reduction in calorie intake over a span of two years. A number of papers have been published on the positive results for participant heath, and researchers continue to produce new analyzes of the data. Here, researchers show that participants who conducted more physical activity while calorie restricted exhibit modestly better outcomes in a number of measures of health known to change favorably with the practice of calorie restriction. It is unclear how physical activity energy expenditure (PAEE) influences calorie restriction (CR)-induced benefits in individuals without obesity. We examined associations between PAEE and healthspan markers and physical activity (PA) time during prolonged CR. In […]
https://www.fightaging.org/arc....hives/2025/10/physic

A Discussion of the Impact of the Gut Microbiome on Aging The composition of the gut microbiome is influential on health, perhaps to a similar degree as diet and exercise choices. This composition changes with age in ways that are detrimental to long-term health, reducing the supply of metabolites necessary for tissue function while increasing the number of microbes capable of provoking chronic inflammatory signaling. Altering the composition of the gut microbiome in lasting ways, such as via flagellin immunization or fecal microbiota transplantation, has been shown to produce benefits to health and longevity in animal studies. Bringing these or related techniques to wider human use remains to be achieved, however, and the presently available approaches of diet and probiotics to adjust the balance of populations in the gut microbiome are not as effective as desired. […]
https://www.fightaging.org/arc....hives/2025/10/a-disc