Reviewing Mitochondrial Dysfunction in Aging Mitochondria are power plants, hundreds of these organelles in every eukaryotic cell, descended from ancient symbiotic bacteria, and now repurposed to generate the chemical energy store molecule adenosine triphosphate (ATP) that is used to power cell processes. Beneath this simple overview lies a very complex and incompletely understood biochemistry. Mitochondria influence many core cell processes, and are influenced in turn. The oxidative byproducts generated by ATP production are both damaging and a signal that can be beneficial. Mildly impairing mitochondrial function can be beneficial to health, if accomplished in certain ways. And so forth. It is clearly the case mitochondria become dysfunctional in cells in aged tissues, as measured in many different ways, and this appears to be an important contribution to the aging process. […]
https://www.fightaging.org/arc....hives/2025/06/review

S-Sulfhydration as an Anti-Inflammatory Mechanism Researchers have investigated the favorable effects of hydrogen sulfide (H2S) on cell metabolism in the context of aging. An increased presence of H2S appears to modestly improve mitochondrial function and autophagy to some degree, thereby reducing oxidative stress and inflammation characteristic of aging. This functions via post-translational modification of important proteins via S-sulfhydration, changing their function. Like most approaches to metabolic manipulation, the effect size is not as large as we might like it to be, and the underlying biochemistry may overlap to some degree with responses to exercise and calorie restriction. Hydrogen sulfide (H2S) and hydrogen polysulfide-induced S-sulfhydration are critical posttranslational modifications that specifically target cysteine residues within proteins. Degenerative diseases are often characterized by oxidative stress and inflammaging, ultimately leading to progressive organ […]
https://www.fightaging.org/arc....hives/2025/06/s-sulf

Pyrroloquinoline Quinone as a Senomorphic Agent Senescent cells accumulate in the aged body, generating a potent mix of pro-inflammatory signaling known as the senescence-associated secretory phenotype (SASP) that is disruptive to tissue structure and function. Over the last decade or so, researchers have devoted an increasing amount of time and effort into firstly understanding these cells, and secondly finding potential ways to reduce their contribution to age-related disease and mortality. While most efforts are directed towards the selective destruction of senescent cells via senolytic therapies, a growing number of projects are identifying senomorphic therapies that might reduce the SASP, and thereby reduce the harmful impact of lingering senescent cells. Such therapies would have to be taken continuously versus the intermittent use of senolytics, but nonetheless papers such as the one noted […]
https://www.fightaging.org/arc....hives/2025/06/pyrrol

Fight Aging! Newsletter, June 30th 2025 Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Reducing Age-Related Peroxisome Degradation Extends Life in Nematodes Physical Activity Correlates with Reduced Epigenetic Age Acceleration Understanding the Aging of the Heart Extracellular Matrix as a Basis for Better Tissue Engineering Increased Protein Disulphide Isomerase Slows Accumulation of DNA […]
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The Double Edged Sword of Therapy Induced Senescence in Cancer Treatment Beyond killing cancerous cells, one of the major goals in traditional chemotherapy and radiotherapy treatment approaches has been to induce senescence in those cells that a therapy fails to kill outright. A senescent cell no longer replicates, and it is the uncontrolled replication of cancerous cells than makes cancer so dangerous. Therefore shutting down that replication was seen as a beneficial outcome, even if the cell survives. Over time, a greater understanding of senescent cells in the broader context of aging and age-related disease has led to a more nuanced view of therapy induced senescence in the context of cancer. Senescent cells secrete inflammatory signals to attract the immune system, to make it pay attention to the local environment. But senescent cells also secrete pro-growth […]
https://www.fightaging.org/arc....hives/2025/06/the-do