Fight Aging! Newsletter, June 2nd 2025 Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out more: https://www.fightaging.org/services/ Contents Expansion of the Montana Right to Try Law Passes Mechanisms of Germline Stem Cell Decline in the Aging of the Testes in Flies A High Level Tour of the Metabolism of Long-Lived Individuals Building an Aging Clock from Microglial […]
https://www.fightaging.org/arc....hives/2025/06/fight-

Arguing for Clinical Trials of Exercise Conditioned Plasma In the context of aging and age-related disease, forms of plasma transfusion remain therapies in search of conclusive proof that the benefits are worth it. Efforts focusing on transfer of young donor plasma into old individuals conducted over the past decade or so have so far failed to produce convincing results in clinical trials. The blood products industry is a large one, and the larger entities in that industry appear to view this as a discovery problem, that somewhere in the fractionation of donor blood there is a way to produce a product that will be modestly useful for some aspects of aging. Looking at the lengthy history of research to establish the production of medical products from donor blood, this may be a reasonable […]
https://www.fightaging.org/arc....hives/2025/05/arguin

The Aging Brain is More Vulnerable to Amyloid-β Toxicity Researchers here demonstrate that old mice are far more vulnerable than young mice to pathology resulting from the introduction of amyloid-β aggregates into brain tissue. Amyloid-β misfolds to form aggregates in the aging brain, and this is thought to be the cause of Alzheimer's disease. Looking at the results here, one might think that this difference between young and old mice is centered around the aging of the immune system. The aged immune system is both more inflammatory and less capable, and the introduction of toxic molecules is thus more likely to provoke a sustained maladative and ineffective response. Aging is the primary risk factor for Alzheimer's disease (AD), and the aging brain shares many characteristics with the early stages of AD. This study investigates […]
https://www.fightaging.org/arc....hives/2025/05/the-ag

Altos Labs Broadens Scope to Senotherapeutics via Acquisition Altos Labs was founded with an enormous amount of capital in order to work on reprogramming as an approach to rejuvenation. They recently acquired a senotherapeutics company, Dorian Therapeutics. Given that we're in the second year of a bad market for biotech fundraising, one might speculate that this was an acquihire. A company in an investor's portfolio runs out of runway, the investor wants to avoid an outright loss, and that overlaps with another portfolio company's desire to rapidly obtain an experienced team. There may or may not be strong-arming on the part of the investor to make it happen. That said, this may also indicate investor pressure for Altos Labs to do something other than run the long-term development programs needed to bring reprogramming […]
https://www.fightaging.org/arc....hives/2025/05/altos-

Building an Aging Clock from Microglial Transcriptomics Any sufficiently complex set of biological data can be used to produce an aging clock via machine learning approaches, generating some combination of values that reflects biological age. This is possible because the burden of damage and dysfunction associated with aging produces characteristic changes in biological data. Novel clocks are published by the research community at a fair pace these days, such as the clock reported in today's open access paper. It was built from transcriptomic data derived from microglia, innate immune cells of the brain. It is a research tool, impractical for medical use given the difficulty of obtaining brain-resident cells from a living individual. The existence of a clock doesn't tell us anything of the way in which the components of the clock […]
https://www.fightaging.org/arc....hives/2025/05/buildi